Table 1.
Application of peptide phage display technology in antibacterial field.
| Target | Bacterial Strain |
Library | Product | Potential Application |
Time | Reference |
|---|---|---|---|---|---|---|
| OprF | P. aeruginosa | Ph.D.-12 peptide library | PA2 (SQRKLAAKLTSK) PA2-GNU7 (SQRKLAAKLTSK-GGGRLLRPLLQLLKQKLR) |
Antimicrobial candidates | 2020 | [15] |
| CR bacteria | CR bacteria | APBA-dimer peptide library | MAK30 (ACmDPNRMDRCm) SEC5(ACmKPLHSRSCm) SEC18(ACmSERQHLQCm) |
Detection of bacteria |
2020 | [16] |
| Cep-1 Ala-2 Lac-4 |
S. aureus MRSA VRE |
Bicyclic peptide libraries (BC-A, BC-B) |
P14 (CQTDVCQRTIC) P15 (CSLITQCGGVGC) P18 (CGGGICRTHNC) |
Antimicrobial candidates | 2019 | [17] |
| LpxA | E. coli | Recombinant M13 phage library | P920 (SSGWMLDPIAGKWSR) CR20 (WMLDPIAGKWSR) |
Antimicrobial candidates | 2019 2003 2006 |
[18,19,20] |
| S. aureus | S. aureus | APBA-dimer peptide library | KAM5 (ACmVSPRSHECm) | Detection of S. aureus | 2018 | [21] |
| A.baumannii | LOS−A. baumannii | APBA-dimer peptide library | KAM8 (ACmTLPNGPRCm) | Detection of LOS− A. baumannii | 2018 | [21] |
| Lipid II | G+ bacteria | Bicyclic peptide library | P8 (ACLLQSLLCPYSTHRCG) P8-D-C10 lipopeptides |
Antimicrobial candidates | 2017 | [22] |
| MDR L. monocytogenes | MDR L. monocytogenes |
Ph.D.-12 peptide library | L2 (DQFVHDVKGTKH) L3 (NSWIQAPDTKSI) |
Antimicrobial candidates | 2016 | [23] |
| Penicillinase | ND | Ph.D.-12 peptide library | P2 (NIYTTPWGSNWS) | Antimicrobial candidates | 2015 | [24] |
| E. coli |
E. coli, P. aeruginosa |
Ph.D.-12 peptide library | EC5 (RLLFRKIRRLKR) | Antimicrobial candidates | 2013 | [25] |
| R-HPr protein | E. coli DH5α | Ph.D.-12 peptide library | AP1 (YQVTQSKVMSHR) | Antimicrobial candidates | 2012 | [26] |
| h31 | E. coli DH5 | Ph.D.-7 - peptide library | CVRPFAL, TLWDLIP | Antimicrobial candidates | 2011 | [27] |
| PC1 β- lactamase |
S. aureus | BLIP combinatorial peptide libraries | BLIP K74G mutant | Further research for BLIP residues |
2011 | [28] |
| B. cereus | B. anthracis | Ph.D.-12 peptide library | BBP-1 (AETVESCLAKSH) BBP-2 (ALTLHPQPLDHP) |
Detection of B. anthracis | 2010 | [29] |
Abbreviations: CR, Colistin-resistant; Cm, APBA-IA modified cysteine; LOS− A. baumannii, lipooligosaccharide deficient A. baumannii; ND, Not detect; R-HPr, Recombinant HPr.