Table 2.
Main pathological and molecular alterations with diagnostic implications in uterine sarcomas.
| LG-ESS | HG-ESS (YMHAE-altered) | HG-ESS (BCOR-altered) | |
|---|---|---|---|
| Characteristics | Uniform cells resembling proliferative-phase endometrial stroma | May be associated with LG-ESS | Myxoid background, spindled and round cell morphology |
| ER/PR | + | − | −/Focal |
| (except areas of LGESS) | |||
| CD10 | + | − | ± |
| Cyclin D1 | − | +++ | +++ |
| BCOR | − | + | ± |
| +++ (BCOR ITD) | |||
| KIT | − | + | |
| Molecular alteration | JAZF1/SUZ12 | YMHAE/NUTM2A-B | ZC3H7B/BCOR fusion |
| JAZF1/PHF1 | Fusion | Or BCOR ITD | |
| fusions | |||
| Prognosis | Good | Bad | Bad |
ITD, internal tándem duplication.