Photographs of affected individuals. Patient 1 shows hypertelorism, medial flaring of eyebrows, ptosis, short philtrum, thick vermillion of upper and lower lips (A), skin hyperextensibility (B and C), severe joint hypermobility (D). Patient 2 with no facial dysmorphism (E). Pedigree of the family and electropherograms show c.616C>T in HNRNPH2 in patient 1 and patient 2 in hemizygous and heterozygous state respectively. Parents had wild type allele (F).