Table 4.
Multivariable logistic regression of factors associated with KP-pneumonia/KP-BSI
| Variable | Unadjusted OR (95%CI) | P-value | Adjusted OR (95%CI) | P-value |
|---|---|---|---|---|
| Male sex (%) | 1.69 (1.03,2.75) | 0.040 | 3.7 (1.44–9.5) | 0.006 |
| Hospitalization ward at KP pneumonia onset | 3.78 (2.26,6.33) | 0.010 | ||
| Chronic cardiac insufficiency | 1.97 (1.13,3.43) | 0.017 | ||
| Chronic renal failure | 3.03 (1.13,8.14) | 0.028 | ||
| Immunosuppressive | 2.565 (1.08,6.10) | 0.033 | 13.52 (2.53,72.22) | 0.002 |
| CRRT | 4.86 (2.59,9.11) | 0.000 | ||
| Mechanical ventilation | 6.49 (3.34,12.61) | 0.000 | 4.96 ( 1.2,20.5) | 0.027 |
| Blood transfusion | 5.85 (3.53,9.70) | 0.000 | ||
| Parenteral nutrition | 1.77 (1.08,2.88) | 0.023 | ||
| central line catheter | 4.26 (2.36,7.69) | 0.000 | ||
| Indwelling urinary catheter | 4.27 (2.12,8.59) | 0.00 | ||
| Prior hospitalizeda | 2.08 (1.36,3.18) | 0.001 | ||
| Prior mechanical ventilationa | 2.94 (1.73,5.00) | 0.000 | ||
| Prior antibiotic exposurea | 1.95 (1.27,2.98) | 0.002 | ||
| Nosocomial infection | 5.46 (3.15,9.47) | 0.000 | ||
| ESBL-KP | 13.89 (8.09,23.86) | 0.000 | 12.93 (5.26–31.76) | 0.000 |
| Inappropriate antimicrobial therapy | 5.96 (3.76,9.46) | 0.000 | 12.38 (5.36–28.58) | 0.000 |
| Days of antibiotic useb > 2.5d | 4.86 (3.13,7.56) | 0.000 | ||
| Days of hospitalizationb > 3.5d | 3.49 (2.26,5.39) | 0.000 | ||
| Days in ICUb > 2.5d | 1.13 (1.07,1.18) | 0.000 | 1.09 (1.02,1.17) | 0.013 |
| APACHE II score > 21 | 4.69 (3.02,7.29) | 0.000 | 3.39 (1.41–8.12) | 0.006 |
| SOFA score > 6.5 | 1.25 (1.18,1.32) | 0.000 | ||
| PCT > 1.8 ng/mL | 6.48 (4.12,10.2) | 0.000 | 6.37 (2.67,5.23) | 0.000 |
| CRP > 162.5 mg/L | 3.75 (2.42,5.8) | 0.000 |
Abbreviations: KP Klebsiella pneumoniae, KP pneumonia /KP-BSI KP pneumonia secondary Klebsiella pneumoniae bloodstream infections, OR odds ratio, CI confidence interval, CRRT Continuous renal replacement therapy, ESBL-positive KP klebsiella pneumoniae isolates producing extended spectrum β-lactamase, ICU Intensive care unit, APACHE Acute physiology and chronic health evaluation, SOFA Sequential organ failure assessment, ALB Albumin, ALT alanine aminotransferase, AST aspartate aminotransferase, TBIL Total bilirubin, SCr Serum creatinine, WBC White blood count, ANC Absolute neutrophil count, HB Hemoglobin, PCT Procalcitonin, CRP C-reactive protein
ain recent 3 months
bbefore sputum culture positive