TABLE 2.

Top SNPs at each locus with P < 5 × 10⁻⁶

				MAF					No. of SNPs in Clump
CHR	dbSNP ID	BP	Minor allele	Cases	Controls	OR (95% CI)	P	IM/GT	Total	GT	IM
10	rs4933352	85,280,795	G	0.42	0.52	0.71 (0.62–0.80)	9.7E-08	IM	2	0	2
16	rs79418449	80,515,374	C	0.04	0.02	2.54 (1.77–3.63)	3.7E-07	GT	1	1	0
3	rs16859966	147,976,678	G	0.17	0.12	1.58 (1.32–1.89)	8.6E-07	IM	45	24	21
5	rs114019803	159,559,041	T	0.02	0.01	3.36 (2.03–5.56)	2.3E-06	IM	3	0	3
4	rs933953	31,356,173	C	0.25	0.32	0.71 (0.62–0.82)	2.6E-06	IM	1	0	1
18	rs116914137	30,589,500	A	0.05	0.02	2.17 (1.57–3.00)	2.8E-06	IM	3	0	3
8	rs7013955	23,343,590	A	0.08	0.05	1.80 (1.40–2.31)	3.7E-06	IM	20	1	19
4	rs116607983	33,372,461	A	0.03	0.01	2.93 (1.86–4.63)	4.0E-06	IM	88	3	85
11	rs141819348	47,698,235	T	0.05	0.03	2.10 (1.53–2.88)	4.6E-06	IM	3	0	3
5	rs2279135	149,637,742	C	0.32	0.27	1.39 (1.21–1.60)	4.8E-06	IM	24	0	24

Results from an association analysis with logistic regression including sex and the first two dimensions of principal-component analysis (PCA) as covariates in 648 cases with MSA and 2898 controls. For an OR < 1, the minor allele has a protective effect, whereas an OR > 1 indicates that the minor allele is associated with an increased risk for development of the disease. Only the leading SNP at each locus with a suggestive association between the disease status and a variant is reported. Table S3 lists all suggestive associations.

SNP, single-nucleotide polymorphism; CHR, chromosome; dbSNP, database of single-nucleotide polymorphism; BP, base-pair coordinates according to human reference genome GRCh38; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval; IM, imputed; GT, genotyped.