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. 2023 Mar 14;15(3):944. doi: 10.3390/pharmaceutics15030944

Figure 5.

Figure 5

RP4 suppresses CRC xenografts growth in vivo without obvious toxicity. (A), Bioluminescence imaging of tumor growth. (B–D), Tumor weight and volume after RP4 treatment (n = 5). (E), Immunohistochemistry analysis of Ki67 and Bcl2 expression in tumor. (F), RP4 induces apoptosis in tumors, assessed by TUNEL. (G), Serum ELISA of xenografted mice treated by PBS, 100mg/kg RP4, 150 mg/kg RP4. (H), ELISA of heart, liver, spleen, lung, and kidney treated by PBS, 100mg/kg RP4, 150 mg/kg RP4. Data are expressed as mean ± S.D. Statistical analysis was performed with one-way ANOVA (n = 3; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001). Representative images from three independent experiments are shown.