Figure 5.

Hypothetical dependences of systolic cardiomyocyte parameters on diastolic sarcomere length. Both peak systolic and diastolic SLs decreased with increasing OM concentrations, and with EMD administration, but not after Levo application (A). Contraction durations increased with increasing OM concentrations, and with EMD administration, but not after Levo application (B). Fractional sarcomere shortening did not increase when diastolic SL decreased following OM administrations; however, it increased by EMD or Levo (C).