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. 2023 Mar 29;21:115. doi: 10.1186/s12916-023-02791-0

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Regulation of CRC progression by macrophage-specific Act1 knockdown. Macrophage-specific Act1 knockdown promoted adenocarcinoma transition through the recruitment of TAMs and CD8⁺ T cells in tumor tissues. By activating STAT3 transcription factors, macrophages-specific Act1knockdown crosstalk with CRC cells and CD8⁺ T cells via CXCL9/10-CXCR3 and PD-1/PD-L1 axis and consequently promoted epithelial-mesenchymal transition and CRC progression. (Figure was created with Biorender.com)