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. 2023 Feb 24;15(3):623. doi: 10.3390/v15030623

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Alterations in miRNA profile of THC-treated, SIV-infected, cART-treated RMs. (A) Volcano plot showing down-(blue) regulated and up-(red) regulated miRNAs in THC/SIV/ART EVs relative to THC/SIV EVs at 1 MPI (left) and 5 MPI (right). (B) Volcano plot showing down-(blue) regulated and miRNAs in THC/SIV/ART ECs relative to THC/SIV ECs at 1 MPI (left) and 5 MPI (right). (C) miRNA-target enrichment analysis showing top target genes by number of interactions for the 13 significantly modulated EV-associated miRNAs (miR-130b-3p, miR-654-3p, miR-28-5p, miR-95-3p, miR-144, miR-1260b, miR-24-3p, miR-206, miR-31-5p, miR-657, miR-139-5p, miR-638, miR-652) at 1 MPI and 5 MPI. (D) Visualization of miRNA-target interaction network for the 13 significantly modulated EV-associated miRNAs. The blue circles represent the miRNAs, while the target genes are represented by the yellow circles. Pathways are represented by blue lines. (E) Dot plot of functional enrichment analysis for the 13 significantly modulated EV miRNAs. Color of dots represent adjusted p-values (FDR) and size of dots represents gene ratio (number of miRNA targets found enriched in each category/number of total genes associated to that category. (F) miRNA-target enrichment analysis showing top target genes by number of interactions for the 7 EC-associated miRNA significantly modulated at 1 MPI and 5 MPI. (G) Visualization of miRNA-target interaction network for the 7 EC-associated miRNA significantly modulated at 1 MPI and 5 MPI. The blue circles represent the miRNAs, while the target genes are represented by the yellow circles. Pathways are represented by blue lines. (H) Dot plot of functional enrichment analysis for target genes of the 7 EC-associated miRNA significantly modulated at 1 MPI and 5 MPI. Color of dots represent adjusted p-values (FDR) and size of dots represents gene ratio (number of miRNA targets found enriched in each category/number of total genes associated to that category.