Table 1.
Animal IDs, SIV inoculum, infection duration, Δ9-THC administration, and ART treatment.
| Animal ID | Pre-Infection Sample Used | SIV Inoculum | Group 1 VEH/SIV |
Group 2 THC/SIV |
Group 3 VEH/SIV/cART |
Group 4 THC/SIV /cART |
Group 5 THC/no SIV |
Post-Infection Sample Collection |
|---|---|---|---|---|---|---|---|---|
| JD66 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| IN24 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| JH47 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| JI45 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| JC85 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| JT80 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| LM56 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| LA88 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| LN60 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| LA55 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| KV50 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| LM85 | NA | SIVmac251 | Yes | 1 & 5 MPI | ||||
| HI78 | NA | SIVmac251 | No | 1 & 5 MPT | ||||
| HN79 | NA | SIVmac251 | No | 1 & 5 MPT | ||||
| HN39 | NA | SIVmac251 | No | 1 & 5 MPT |
NA—Not applicable. MPI—Months post infection. MPT—Months post treatment. Macaques in groups 3 and 4 received two injections of (50 mg/kg of anti-alpha4beta7) (LN60 and LM85) or control IgG (LM56) beginning 4 MPI at three-week intervals before the plasma sample at 5 MPI was collected. Macaques LN60, LM56, and LM85 received ART until 6 MPI. Macaques LA88, LA55, and KV50 received ART until 8 MPI (Table 2). However, samples used for this study were collected at 1 and 5 MPI.