Table 4.
Serum oxidative stress markers in rat turpentine-induced inflammation model.
| GROUPS | TOS (µM H2O2 E/L) |
OSI | TAC (mM TE/L) |
NOx (µM/L) |
MDA (nM/L) |
SH (mM/L) |
NF-κB (ng/mL) |
|---|---|---|---|---|---|---|---|
| CONTROL | 5.13 ± 0.84 | 4.70 ± 0.77 | 1.0901 ± 0.001 | 32.67 ± 2.38 | 1.91 ± 0.19 | 0.52 ± 0.05 | 2.2 ± 0.22 |
| INFLAMM | 8.55 b ± 0.73 | 8.54 b ± 0.66 | 1.0873 ± 0.001 | 45.34 b ± 3.53 | 3.00 b ±0.21 | 0.25 b ± 0.02 | 4.17 a ± 0.99 |
| DICLOFENAC | 7.84 ± 0.35 | 7.84 ± 0.32 | 1.0870 ± 0.000 | 41.48 ± 2.11 | 2.94 ± 0.39 | 0.31 ± 0.04 | 2.41 f ± 0.32 |
| TOT 100 | 4.92 e ± 0.24 | 4.92 e ± 0.22 | 1.0871 ± 0.001 | 37.59 g ± 5.43 | 3.20 g ± 0.66 | 0.20 d ± 0.02 | 2.92 cg ± 0.60 |
| TOT 50 | 5.15 e ± 0.72 | 5.15 e ± 0.67 | 1.0878 ± 0.001 | 37.00 g ± 3.89 | 2.91 g ± 0.39 | 0.24 ± 0.02 | 3.64 ± 0.51 |
| TOT 25 | 4.63 e ± 0.30 | 4.63 e ± 0.27 | 1.0886 ± 0.000 | 30.32 d ± 7.13 | 3.06 g ± 0.72 | 0.27 g ± 0.11 | 3.52 ± 0.37 |
Note: Values are expressed as mean ± SD (n = 5). a p < 0.05, b p < 0.001 versus CONTROL; c p < 0.05, d p < 0.01, e p < 0.001 versus INFLAMM. f p < 0.05 versus INFLAMM. g p > 0.05 versus DICLOFENAC. TOS—total oxidative status, OSI—oxidative stress index, TAC—total antioxidant capacity, Nox—total levels of nitrites and nitrates, MDA—malondialdehyde, SH—total levels of thiols, NF-kB—Nuclear factor kappa-light-chain-enhancer of activated B cells, CONTROL—healthy animals group, INFLAMM group—negative control, DICLOFENAC group—positive control.