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. 2023 Mar 13;24(6):5503. doi: 10.3390/ijms24065503

Figure 4.

Figure 4

Analysis of EquiPEA™ on CB1/2 receptors and GABA activity under PNI conditions In (A) cannabinoid receptor type 1 (CB1R) and in (B) cannabinoid receptor type 2 (CB2R) densitometric analysis of the specific Western blot, which is reported as an example in (C); in (D,E) gamma-aminobutyric acid (GABA) activity by ELISA test in the absence or presence of CB1/2 blockers. The data are the mean ± SD (%) of five independent experiments performed in triplicate and normalized to control values (the 0% line). The abbreviations are the same as those reported in Figure 3. In (A): a, b, d, e, p < 0.05 vs. control; a p < 0.05 vs. b–e; b p < 0.05 vs. c, d; c p < 0.05 vs. d, e; d p < 0.05 vs. e. In (B): a, b, d, e, p < 0.05 vs. control; a p < 0.05 vs. b–e; b p < 0.05 vs. c, d; c p < 0.05 vs. d, e; d p < 0.05 vs. e. In (D): a, b, d, e p < 0.05 vs. control; a p < 0.05 vs. b–e; b p < 0.05 vs. c, d; c p < 0.05 vs. d, e; d p < 0.05 vs. e. In (E): e–g p < 0.05 vs. control; e p < 0.05 vs. g; f p < 0.05 vs. g; g p < 0.05 vs. h.