Table II.

Composition of factorial formulations designed by Design-Expert^® software.

Points	Replication	Coded level		Actual level of variables
		PF	T	PF (mg/ml)	T (IU/ml)
(−1,0)	2	−1	0	15	50
(0,−1)	2	0	−1	45	20
(0,0)	5	0	0	45	50
(0,+1)	2	0	+1	45	80
(+1,0)	2	+1	0	75	50
(−α,−α)	2	−α	−α	20	25
(−α,+α)	2	−α	+α	20	75
(+α,−α)	2	+α	−α	70	25
(+α,+α)	2	+α	+α	70	75

PF, PEGylated fibrinogen; T, thrombin.