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. 2023 Mar 28;24:58. doi: 10.1186/s13059-023-02900-5

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Overview of HiCAT. a Generation of the block list and similarity matrix. b Mining of higher-order repeats (HORs). $t_{d}$ represents the similarity threshold in the current iteration. $t_{d + 1}$ represents the similarity threshold in the next iteration. $t_{\min}$ is the minimum similarity threshold. $step$ is the threshold increase for each iteration. For example, $t_{0} = 94 %$ and $t_{1} = t_{0} + 0.5 % = 94.5 %$ . $S_{i, j}$ is the similarity between block $i$ and block $j$ . HTRM: hierarchical tandem repeat mining. Colored rectangles in the monomer sequence represent monomers