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. 2023 Mar 18;15(6):1467. doi: 10.3390/nu15061467

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of aspartame or aspartame metabolites on mitochondrial integrity and cellular oxidative stress. Neuroblastoma cells (SH-SY5Y) were treated with control, aspartame, or aspartame metabolites as described before. Afterwards, the levels of cardiolipin (A) and APF (B), as well as gene expression levels of FIS1 (C), PINK1 (D), SOD1, and SOD2 (E), were detected. A comparison of the corresponding changes in aspartame- and metabolite-treated SH-SY5Y cells is illustrated by bar charts. Error bars represent the standard error of the mean (SEM) and the statistical significance was set as * p ≤ 0.05 and *** p ≤ 0.001 (n.s.: not significant).