Table 1.
Characteristics of the peptides.
| No. | Peptide | Sequence | Net Charge | No. of Carbons Atoms in Lipophilic Entity |
HPLC tR (min) |
|---|---|---|---|---|---|
| I | KR12-NH2 | KRIVQRIKDFLR-NH2 | +5 | 0 | 3.81 |
| II | C8α-KR12-NH2 | C8-KRIVQRIKDFLR-NH2 | +4 | 8 | 6.71 |
| III | C8ε-KR12-NH2 | K(C8)RIVQRIKDFLR-NH2 | +4 | 8 | 5.24 |
| IV | C8α-Lys-KR12-NH2 | C8-KKRIVQRIKDFLR-NH2 | +5 | 8 | 5.24 |
| V | C8ε-Lys-KR12-NH2 | K(C8)KRIVQRIKDFLR-NH2 | +5 | 8 | 4.99 |
| VI | KR12-Lysε(C8)-NH2 | KRIVQRIKDFLRK(C8)-NH2 | +5 | 8 | 4.91 |
| VII | [Lysε(C8)]12KR12-NH2 | KRIVQRIKDFLK(C8)-NH2 | +4 | 8 | 5.17 |
| VIII | [Lysε(C8)]8KR12-NH2 | KRIVQRIK(C8)DFLR-NH2 | +4 | 8 | 5.25 |
| IX | C8α,C8ε-KR12-NH2 | C8-K(C8)RIVQRIKDFLR-NH2 | +3 | 16 | 9.24 |
| X | C4α, C4ε-KR12-NH2 | C4-K(C4)RIVQRIKDFLR-NH2 | +3 | 8 | 6.29 |
| XI | retro-KR12-C8ε-NH2 | RLFDKIRQVIRK(C8)-NH2 | +4 | 8 | 5.05 |
| XII | C8α-retro-KR12-NH2 | C8-RLFDKIRQVIRK-NH2 | +4 | 8 | 5.64 |
| XIII | 2-Buthyloctanoic acid-KR12-NH2 | CH3-(CH2)5-CH(C4H9)-CO-KR12-NH2 | +4 | 12 | 7.85 |
| XIV | 2-Ethylhexanoic acid-KR12-NH2 | CH3-(CH2)3-CH(C2H5)-CO-KR12-NH2 | +4 | 8 | 6.37 |
| XV | Benzoic acid-KR12-NH2 | C6H5-CO-KR12-NH2 | +4 | 7 | 5.65 |
| XVI | Phenylacetic acid-KR12-NH2 | C6H5-CH2-CO-KR12-NH2 | +4 | 8 | 5.76 |
| XVII | 3-Phenylpropionic acid- KR12-NH2 | C6H5-CH2-CH2-CO-KR12-NH2 | +4 | 9 | 6 |
| XVIII | 4-Phenylbutanoic acid-KR12-NH2 | C6H5-(CH2)3-CO-KR12-NH2 | +4 | 10 | 6.21 |
| XIX | trans-cinnamic acid-KR12-NH2 |
C6H5-CH=CH-CO-KR12-NH2 | +4 | 9 | 6.06 |
| XX | Phenylpropiolic acid-KR12-NH2 | C6H5-C≡C-CO-KR12-NH2 | +4 | 9 | 5.76 |
| XXI | 4-Phenylbenzoic acid- KR12-NH2 | C6H5-C6H4-CO-KR12-NH2 | +4 | 13 | 6.53 |
| XXII | Deoxycholic acid- KR12-NH2 | C24H39O3-KR12-NH2 | +4 | 24 | 7.73 |