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Histological images of human skin fragments immediately after ulcer induction (D0) and after 14 days of daily application of different numbers of NC and Nano-1 particles. (A) 1.3 × 1012 particles/mL, (B) 6.5 × 1011 particles/mL, and (C) 3.2 × 1011 particles/mL. Hematoxylin-eosin staining. 100× magnification. Solid arrows indicate the onset of ulceration, while dashed arrows indicate the lining of new epithelium.
