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. 2023 Mar 10;15(3):910. doi: 10.3390/pharmaceutics15030910

Table 2.

Weight loss (WL) after the freeze-drying process; physicochemical properties of the lyophilized sample (pycnometric density (PD); bulk density (BD); tapped density (TD); Hausner ratio (HR); Carr’s compressibility index (CI); pH leaching; moisture content (MC); wetting time (WT); water absorption ratio (WA)) ± calculated SD.

Sample WL (%) PD (g/mL) TD (g/mL) BD (g/mL) HR CI pH MC (%) WT (s) WA (%)
LP_US2_IN 75.25 ± 1.77 1.84 ± 0.00 0.32 ± 0.00 0.38 ± 0.00 1.19 ± 0.01 16.06 ± 0.75 5.13 ± 0.01 2.75 ± 0.54 0.77 ± 0.25 167.79 ± 4.87
LP_US2_SA 79.09 ± 3.97 1.79 ± 0.00 0.40 ± 0.00 0.44 ± 0.00 1.10 ± 0.01 8.85 ± 0.90 5.02 ± 0.01 2.40 ± 0.77 1.67 ± 0.58 97.55 ± 8.63
LP_US2_ST 70.78 ± 1.54 1.80 ± 0.07 0.26 ± 0.01 0.30 ± 0.00 1.16 ± 0.04 13.69 ± 3.27 5.03 ± 0.00 3.61 ± 0.65 5.67 ± 0.58 299.75 ± 6.75
LP_NS2N_IN 79.49 ± 2.99 1.84 ± 0.01 0.38 ± 0.02 0.43 ± 0.01 1.13 ± 0.04 11.49 ± 3.41 5.01 ± 0.01 2.85 ± 0.13 7.53 ± 0.50 127.01 ± 9.25
LP_NS2N_SA 71.85 ± 2.24 1.75 ± 0.00 0.41 ± 0.01 0.46 ± 0.00 1.12 ± 0.02 10.83 ± 1.44 5.02 ± 0.01 1.85 ± 0.79 2.60 ± 0.53 55.49 ± 2.22
LP_NS2N_ST 59.98 ± 1.88 1.81 ± 0.00 0.30 ± 0.00 0.34 ± 0.00 1.16 ± 0.00 13.89 ± 0.00 4.90 ± 0.01 1.04 ± 0.30 2.70 ± 0.27 287.92 ± 5.17
LP_AV_IN 77.64 ± 2.37 1.55 ± 0.00 0.35 ± 0.01 0.44 ± 0.00 1.25 ± 0.02 20.17 ± 1.26 3.68 ± 0.01 2.24 ± 0.32 11.43 ± 1.25 64.62 ± 7.93
LP_AV_SA 74.49 ± 2.28 1.65 ± 0.00 0.41 ± 0.01 0.44 ± 0.00 1.08 ± 0.02 7.53 ± 1.88 3.68 ± 0.00 1.55 ± 0.24 3.93 ± 0.12 39.35 ± 6.86
LP_AV_ST 76.74 ± 0.82 1.59 ± 0.00 0.27 ± 0.00 0.34 ± 0.00 1.23 ± 0.02 18.79 ± 1.28 3.72 ± 0.01 2.42 ± 0.26 5.33 ± 0.15 219.13 ± 6.93
LP_IN 80.50 ± 0.57 1.61 ± 0.01 0.34 ± 0.00 0.44 ± 0.01 1.29 ± 0.01 22.38 ± 0.83 3.68 ± 0.01 1.30 ± 0.57 2.77 ± 0.25 24.70 ± 7.19
LP_SA 76.90 ± 1.30 1.64 ± 0.01 0.32 ± 0.00 0.36 ± 0.01 1.13 ± 0.03 11.43 ± 2.47 3.68 ± 0.00 0.57 ± 0.30 0.77 ± 0.25 88.54 ± 4.41
LP_ST 81.76 ± 1.27 1.64 ± 0.01 0.27 ± 0.01 0.34 ± 0.00 1.25 ± 0.06 20.07 ± 3.73 3.69 ± 0.01 2.29 ± 0.36 7.83 ± 0.76 307.32 ± 6.28
LP_US2 86.00 ± 0.69 2.06 ± 0.15 0.23 ± 0.01 0.24 ± 0.01 1.05 ± 0.02 4.99 ± 1.65 4.88 ± 0.01 4.28 ± 0.17 0.70 ± 0.30 226.58 ± 7.02
LP_NS2N 82.94 ± 2.68 2.06 ± 0.00 0.25 ± 0.00 0.29 ± 0.00 1.15 ± 0.01 12.90 ± 0.69 5.00 ± 0.00 2.84 ± 0.58 0.60 ± 0.17 191.83 ± 1.10
LP_AV 82.43 ± 1.51 1.68 ± 0.02 0.34 ± 0.00 0.41 ± 0.01 1.22 ± 0.02 17.65 ± 1.62 3.74 ± 0.01 1.92 ± 0.11 0.43 ± 0.12 94.83 ± 6.01
LP 94.93 ± 0.18 2.24 ± 0.01 0.28 ± 0.00 0.33 ± 0.00 1.17 ± 0.00 14.29 ± 0.00 3.71 ± 0.01 0.41 ± 0.09 N/A * N/A

* N/A—not applicable.