Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Mar 28;55(1):1262–1286. doi: 10.1080/07853890.2023.2191218

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

PMC Copyright notice

Figure 4. — Melatonin regulates insulin secretion in pancreatic β-cells via the cAMP, cGMP and IP3 signaling pathways [98,236]. The binding of melatonin to MT1 inhibits cyclic adenosine monophosphate (cAMP) signaling and decreases insulin secretion in pancreatic β-cells. The binding of melatonin to MT2 inhibits cyclic guanosine monophosphate (cGMP) signaling and decreases insulin secretion in pancreatic β-cells. Melatonin stimulates IP3 release accompanied by a transient increase in Ca²⁺ concentrations and leads to Ca²⁺-dependent insulin secretion. Figure 3 was created with BioRender (https://biorender.com).