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The binding of melatonin to MT1 stimulates glycogen synthesis in hepatic cells via the protein kinase Cζ (PKCζ)-Akt-glycogen synthase kinase 3B (GSK3β) pathway [102]. Melatonin increases the phosphorylation of PKCζ, Akt, and GSK3β and stimulates glycogen synthesis in hepatic cells. Figure 5 was created with BioRender (https://biorender.com).
