Table 3.
The different genetic effects of MTNR1B on glycemic traits in overweight/obesity individuals.
| Reference | Study population | Risk allele | subgroup | B-estimate (SEM)/OR (95% CI) |
|---|---|---|---|---|
| [210] | 310 children and adolescents, aged 8-19 years, Caucasian populations. |
rs10830963-G | BMI-SDS < 2.5 | Reference |
| 2.5 ≤ BMI-SDS < 3.0 | 0.209 (0.093) mmol/L increase of FBG 0.144 (0.178) decrease of HOMA–B |
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| BMI-SDS ≥ 3.0 | 0.265 (0.091) mmol/L increase of FBG 0.380 (0.174) decrease of HOMA–B |
|||
| [211] | 1002 adult obese subjects, aged 26–66 years, Caucasian populations. |
rs10830963-G | 1.31 (1.12–2.78) increase the odds of hyperglycemia 1.37 (1.14–2.86) increase the odds of diabetes mellitus |
|
| [212] | 781 obese children and adolescents, mean aged 13.4 ± 3.6 year, 346 Caucasians, 218 African–Americans, 217 Hispanics. |
rs10830963-G | African–Americans Hispanics |
3.72 (1.36–10.12) increase the odds of IFG 2.50 (1.01–6.18) increase the odds of IFG |
| Caucasians | 3.12 (1.41–6.88) increase the odds of IFG and IGT | |||
| African–Americans | 3.29 (1.203–8.98) increase the odds of risk of IGT | |||
| [213] | 1,118 overage children and adolescents, aged 6–16 years, Caucasian populations. |
rs10830963-G | 1.101 (0.316—1.886) mg/dL increase of FBG | |
| [203] | 2772 pregnant women | rs10830963-G | Pre-pregnancy BMI <25 | 1.22 (0.9, 1.65) |
| Pre-pregnancy BMI ≥25 | 1.24 (1.02–1.51) increase the odds of GDM | |||
| [214] | 211 GDM patients Caucasian populations |
rs10830963-G | Pre-pregnancy BMI <29 | 1.36(NA) |
| Pre-pregnancy BMI ≥29 | 5.2(1.3–20.8) increase the odds of |
BMI-SDS: body mass index standard deviation score; HOMA-B: homeostasis model assessment of β-cell function; AIT: antenatal insulin therapy; FBG: fasting blood glucose; IFG: impaired fasting glucose; IGT: impaired glucose tolerance; GDM: gestational diabetes.