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Pathogenesis of SARS-CoV-2. Abbreviations: ACE2: angiotensin converting enzyme 2; TMPRSS2: transmembrane serine protease 2; CatB/L: cathepsin B/L; RBD: receptor-binding domain; nsps: nonstructural proteins; pp1a: polyproteins 1a; pp1ab: polyproteins 1ab; 3CLpro: 3C-like protease; Mpro: main protease; PLpro: papain-like protease; RdRp: RNA-dependent RNA polymerase.
