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. 2023 Mar 26;15(1):2192155. doi: 10.1080/19490976.2023.2192155

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 1. — Profile of the bile acids and gut microbiota in individuals with T2DM. a Sex proportions and FBG distribution in T2DM and Control. b OPLS-DA plot of bile acids levels in T2DM (blue) and Control (orange). c Determination of serum bile acids in T2DM and Control group. P values were analyzed by two-tailed Mann–Whitney U-test and data were presented as medians. d ROC of GUDCA in predicting T2DM. AUC: area under curve. e Analysis with the linear discriminant analysis (LDA). Green indicates enriched taxa in the T2DM group. Red indicates enriched taxa in the Control group. f Different species abundance of T2DM and Control based on metagenomics data. n=15 individuals/groups. *p＜0.05，**p＜0.01.