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. 2023 Mar 26;15(1):2192155. doi: 10.1080/19490976.2023.2192155

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 2. — GUDCA supplementation had therapeutic effects in improving glucose tolerance. a Fasting blood glucose. b, c OGTT, ITT and AUC. Vehicle or GUDCA-treated (100 mg/kg/d) mice on db/db mice for 8 weeks. n=10 mice in m/m group, n=9 mice in db/db+veh and db/db+gudca groups. All P values were analyzed by two-tailed Student’s t-test, **p< 0.01 versus m/m; #p< 0.05, ##p< 0.01 versus db/db+veh. All data are presented as the mean ± sd. d HOMA-IR. E TC and TG in the serum. f Serum active GLP1 levels. n=8 mice/group. All P values were analyzed by two-tailed Student’s t-test, *p< 0.05, **p< 0.01. All data are presented as the mean ± sd.