Table 1.
Summarization of gene and SNPs associated with IR and atherosclerosis.
| Gene | SNP ID | Position | Parameter Association | Population | N | p-Value | Ref |
|---|---|---|---|---|---|---|---|
| CHI3L1 | rs946263 | −9639 C > G | G-allele was nominally found to be associated with T2DM | Danish | 9438 | 0.027 | [63] |
| Was associated with serum Ykl-40 levels | Danish | 6784 | <0.0001 | [64] | |||
| −2122 C > T | Was associated with LDL level (cause of atherosclerosis) | Korean | 290 | 0.005 | [65] | ||
| Was associated with a significantly increased CHI3L1 mRNA level in peripheral blood cells and elevated nuclear factor binding | 0.008 | ||||||
| CD36 | rs1761667 | −31118 G > A | Was associated with T2DM | North Indian | 400 | <0.001 | [66] |
| Was associated with lipid profile | <0.001 | ||||||
| Was associated with LDL | <0.05 | ||||||
| Was associated with VLDL | 0.029 | ||||||
| A > G | CAD patients with an AG genotype had higher plasma levels of LDL | Egyptian | 100 | 0.046 | [67] | ||
| LEPR | rs1137100 | 109 T > A | Was independently associated with early atherosclerosis | Finnish | 526 | 0.042 | [68] |
| Was associated with high total cholesterol | 0.005 | ||||||
| Was associated with insulin levels | |||||||
| RETN | rs1862513 | −420 C > G | Was associated with resistin levels in DM patients | Japanese | 198 | 2.9 × 10−7 | [69] |
| Was associated with HbA1c levels | |||||||
| Was associated with total cholesterol levels (CAD marker) | Pakistani | 350 | <0.0001 | [70] | |||
| Was associated with LDL levels (CAD marker) | 0.0067 | ||||||
| Was associated with resistin levels | 0.0009 | ||||||
| Was associated with hs-CRP levels (CAD marker) | <0.0001 | ||||||
| rs3745367 | +299 G > A | Significantly associated with T2DM | Thai | 95 | 0.004 | [71] | |
| Associated with total cholesterol levels | Pakistani | <0.0001 | [70] | ||||
| Associated with LDL levels | 0.0153 | ||||||
| Associated with resistin levels | <0.0001 | ||||||
| Associated with hs-CRP levels | <0.0001 | ||||||
| IL-18 | rs1834481 | G > C | Associated with CAD/ MI risk | European | 3202 | 0.0021 | [72] |
| Associated with IL-18 levels | European | 200 | <0.005 | [73] | |||
| Associated with glucose levels | <0.005 | ||||||
| RBP-4 | rs7094671 | G > A | Associated with CAD | Chinese | 392 | <0.0001 | [74] |
| +5169 C > T | Associated with T2DM | Mongolian | 281 | <0.005 | [75] | ||
| RARRES2 | rs17173608 | T > G | Associated with risk of metabolic syndrome (IR, high LDL) | Iranian | 300 | 0.012 | [57] |