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. 2023 Mar 13;12(6):2219. doi: 10.3390/jcm12062219

Table A2.

Risk of Bias assessment according to SIGN methodology checklist.

Author 1. Question 1. Selection 1. Assessment 1. Confounding 1. Statistical Analysis 2. Quality Notes
Dahan et al. [18] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = High
1.5 = 7% 1.10 = Yes 2.2 = Yes
1.6 = Yes 1.11 = Yes 2.3 = Yes
Kabukçu et al. [19] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = 10% 1.10 = Yes 2.2 = Yes
1.6 = Yes 1.11 = Yes 2.3 = Yes
Agarwal et al. [20] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = Low n = 7, therefore low quality.
1.5 = Not reported 1.10 = Yes 2.2 = No
1.6 = NA 1.11 = Yes 2.3 = Yes
Borges et al. [21] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = High
1.5 = 0% 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Vahidi et al. [22] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = 0% 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Comar et al. [23] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = High
1.5 = 0% 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Uppangala et al. [24] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Missing confidence intervals.
1.5 = Not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Sánchez-Martín et al. [25] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = No 1.14 = No 2.1 = Low Both insufficient confounding assessment and missing confidence intervals.
1.5 = Not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Scarselli et al. [26] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = 0% 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Shen et al. [27] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = Not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Gosálvez et al. [28] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Can’t say 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = Not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3= Yes
Jurema et al. [29] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Can’t say 1.14 = No 2.1 = Acceptable Retrospective design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Mayorga-Torres et al. [30] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Low n = 6, therefore low quality.
1.5 = 0% 1.10 = Yes 2.2 = No
1.6 = NA 1.11 = Yes 2.3 = Yes
Jonge et al. [31] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Low n = 11, therefore low quality.
1.5 = 30% 1.10 = Yes 2.2 = No
1.6 = Yes 1.11 = Can’t say 2.3 = Yes
Kulkarni et al. [32] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable
1.5 = not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Marshburn et al. [33] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Can’t say 1.14 = No 2.1 = Acceptable Retrospective design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Barbagallo et al. [34] 1.1 = Ýes 1.2 = Can’t say 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable
1.5 = Not reported 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Kably-Ambe et al. [35] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Can’t say 1.14 = No 2.1 = Acceptable Retrospective design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Gupta et al. [36] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = Acceptable High quality study but cannot rate higher than acceptable because of retrospective study design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Manna et al. [37] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Went from high to acceptable quality, because of missing confidence intervals.
1.5 = 1.5% 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Azizi et al. [38] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = Acceptable High quality study but cannot rate higher than acceptable because of retrospective study design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Welliver et al. [39] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Can’t say 1.14 = No 2.1 = Acceptable
1.5 = 5% 1.10 = Yes 2.2 = Yes
1.6 = Can’t say 1.11 = Yes 2.3 = Yes
Periyasamy et al. [40] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = Yes 2.1 = Acceptable High quality study but cannot rate higher than acceptable because of retrospective study design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes
Lee et al. [41] 1.1 = Yes 1.2 = Yes 1.7 = Yes 1.13 = Yes 1.14 = No 2.1 = Acceptable Retrospective design.
1.5 = NA retrospective 1.10 = Yes 2.2 = Yes
1.6 = NA 1.11 = Yes 2.3 = Yes

NA: not applicable. Questions that were not relevant for our study were removed. In the selection section 1.3 and 1.4 were not applicable and in the assessment section 1.8, 1.9 and 1.12 were not applicable.