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. 2023 Mar 17;24(6):5782. doi: 10.3390/ijms24065782

Figure 3.

Figure 3

Coactivator and corepressor complexes of CYP11B2 promoter region. Binding activities of coactivator complexes, such as CREB (cyclic AMP responsive element binding protein), NURR1 (nuclear receptor-related factor 1), and corepressor complex MECP2 (methyl-CpG-binding protein 2) are regulated by DNA methylation. Methylation of CpG1 greatly decreased CREB1 binding to Ad1 (cis-acting element 1). DNA methylation at CpG2 reduced basal binding activities of NGF1B (nerve growth factor-induced clone B) (NR4A1) and NURR1 (NR4A2) with Ad5. DNA methylation increased MECP2 binding to CpG1 and CpG2. NR4A, nuclear receptor 4 group A; Sin3A, SIN3 transcription regulator family member A.