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(A) Effect of potassium on CYP11B2 mRNA and protein level. In CYP11B2 mRNA level, results are given as fold change normalized to ACTB. * p < 0.01 and ** p < 0.005 vs. K(−). K(−) indicates H295R cells treated with no additional potassium. (B) Potassium-induced recruitment of CREB1 and NR4A1 in the CYP11B2 promoter. (a), CREB1 recruitment to Ad1; (b), NR4A1 (NGFI-B) recruitment to Ad5. ** p < 0.005 and *** p < 0.0001 vs. K(−).
