Table 1.
Prognostic importance of NLR in testicular cancer patients.
| Author (Year) |
Reference | Patients (n) | Study Design | Cut-Off Value | Main Findings |
|---|---|---|---|---|---|
| Yuksel (2016) |
[35] | 36 | Cross-sectional | - | NLR was significantly elevated in TC patients compared with the control group |
| Jankovich (2017) |
[32] | 103 | Retrospective cohort |
4.0 | NLR < 4 was a predictor of non-metastatic disease NLR > 4 was associated with stage > T1 |
| Bolat (2017) |
[36] | 53 | Retrospective cohort |
3.55 for PFS 3.0 for CSS |
Preoperative NLR was not a reliable predictor of PFS and CSS |
| Gokcen (2018) |
[33] | 39 | Cross-sectional | - | NLR was significantly elevated in TC patients compared with the control group |
| Fankhauser (2018) | [40] | 146 | Retrospective cohort |
4.5 | NLR > 4.5 was associated with poor OS in metastatic GCT patients undergoing first-line CHT |
| Tan (2019) |
[37] | 160 | Retrospective cohort |
3.0 | NLR > 3 was a significant predictor of poor CSS, lymph node involvement, and metastatic disease |
| Herraiz-Raya (2019) | [38] | 164 | Retrospective cohort |
4.0 | NLR > 4 was associated with advanced stage of disease and poor OS |
| Cursano (2020) |
[42] | 146 | Retrospective cohort |
4.5 | NLR > 4.5 was significantly correlated with poor OS in metastatic GCT patients |
| Ariman (2021) |
[34] | 152 | Cross-sectional | - | NLR was significantly elevated in TC patients compared with the control group Patients with intermediate and poor IGCCCG prognosis had significantly elevated NLR compared with patients with good IGCCCG prognosis |
| Bumbasirevic (2022) | [39] | 88 | Prospective cohort |
2.685 | NLR > 2.685 was associated with metastatic disease NLR was significantly increased in Stage II and III patients compared with Stage I patients NLR was associated with 8-hydroxydeoxyguanosine, a representative byproduct of oxidative DNA damage |
NLR, neutrophile-to-lymphocyte ratio; TC, testicular cancer; PFS, progression-free survival; CSS, cancer-specific survival; CHT, chemotherapy; OS, overall survival; IGCCCG, International Germ Cell Cancer Collaborative Group.