Table 4.
Prognostic importance of NLR in penile cancer patients.
| Author (Year) |
Reference | Patients (n) | Study Design | Cut-Off Value | Main Findings |
|---|---|---|---|---|---|
| Kasuga (2016) |
[65] | 41 | Retrospective cohort |
2.82 | NLR > 2.82 highly correlated with poor OS and CSS and pN+ disease |
| Tan (2017) |
[66] | 39 | Retrospective cohort |
2.8 | NLR > 2.8 was associated with poor CSS |
| Azizi (2019) |
[67] | 84 | Retrospective cohort |
3.0 | NLR > 3 was significantly associated with a higher stage of disease, pN+ disease, ENE and poor OS |
| Li (2020) |
[70] | 228 | Retrospective cohort |
- | Elevated NLR highly correlated with worse CSS |
| Hu (2020) |
[68] | 225 | Retrospective cohort |
2.94 | NLR > 2.94 was associated with pN+ disease NLR > 2.94 highly correlated with poor OS and PFS, but only in univariate analysis |
| Jindal (2021) |
[69] | 69 | Retrospective cohort |
3.0 | NLR > 3 was associated with pN+ disease and poor CSS |
NLR, neutrophile-to-lymphocyte ratio; OS, overall survival; CSS, cancer-specific survival; pN+ disease, pathological inguinal lymph node involvement; ENE, extranodal extension; PFS, progression-free survival.