The interaction between the three mycotoxins and microorganisms, including viruses, bacteria, and parasites. These three mycotoxins can promote various types of virus replication, including porcine epidemic diarrhea virus (PEDV), porcine reproductive and respiratory syndrome virus (PRRSV), swine influenza virus (SIV), human immunodeficiency virus (HIV), and porcine circovirus type 2 (PCV2). In turn, PCV2 and PRRSV can aggravate the toxic effect of mycotoxins. The three mycotoxins can increase or reduce the number of bacteria, and some beneficial bacteria can protect the body against damage induced by mycotoxins. Mycotoxins also increase the proliferation of coccidiosis. (+) represents the promoted function; (−) represents the inhibitory function. Red and green lines represent harmful and beneficial functions, respectively.