Table 2.
Effects of AFB1 exposure on SIV replication in multiple cell lines [12].
| Concentration of AFB1 (μg/mL) |
MDCK | A549 | PAMs | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Viral Titer | Viral M mRNA Levels | Viral NP Levels | Viral Titer | Viral M mRNA Levels | Viral NP Levels | Viral Titer | Viral M mRNA Levels | Viral NP Levels | |
| 0.01 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ |
| 0.025 | - | - | - | - | - | - | ↑ | ↑ | ↑ |
| 0.05 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ |
| 0.25 | ↑ | ↑ | ↑ | ↑ | ↑ | ↑ | - | - | - |
The effect of AFB1 on the replication of the H1N1 swine influenza virus (SIV) was studied by in vitro infection. Viral titer, M protein mRNA levels, and NP protein levels were detected to assess the level of H1N1 replication. AFB1: Aflatoxin B1; MDCK: Madin-Darby canine kidney cells; A549, human non-small cell lung cancer cells; PAMs: porcine alveolar macrophages.