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[Preprint]. 2023 Mar 16:2023.03.15.532610. [Version 1] doi: 10.1101/2023.03.15.532610

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Extended Data Fig. 8 | — a, ConSurf plot for OCT2cs and OCT2 homologs. b, Electrostatics surface of outward occluded OCT2, calculated by APBS. c, local conformational changes in the N-lobe from outward open (blue) to outward occluded (green) conformations. d, Concerted local conformational changes in TM2 and 11 leads to extracellular gate formation.