Figure 3 |. Verapamil recognition by OCT1.

a, Detailed VPM-OCT1 interactions in the binding cavity, highlighting interacting residues. b, Orthosteric and allosteric moieties of VPM (left), with shared and distinct interacting residues between VPM and DPH (right). c, Enantiospecific recognition of VPM by OCT1_CS, as shown by IC₅₀ measurements of S(−) or R(+) VPM against OCT1_CS mediated ³H-MPP⁺ uptake activity (30 minute uptake with 100 nM ³H-MPP⁺; n=3 individual biological replicates shown, IC₅₀ ± s.e.m.).