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[Preprint]. 2023 Mar 16:2023.03.15.532610. [Version 1] doi: 10.1101/2023.03.15.532610

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Fig. 5 | — a, Overview of the two distinct OCT conformations: outward open (VPM-OCT1_CS) and outward occluded (MPP⁺-OCT2_CS) b, Ligand binding pose for MPP⁺-OCT2_CS, showing MPP⁺ (navy), and interacting residues of OCT2. N- and C- domains are colored blue and pink, respectively. c, Structural comparisons among the three observed conformations. Left, overall C-domain changes as well as TM7–8, TM11–12 conformational changes. Right, the conformational changes result in the formation of the thin and thick gates. d, Proposed OCT alternate access transport mechanism based on structural observations.