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Kinetic parameters of IMPDH2 variants compared to WT IMPDH2.
| Variant | IMP | NAD+ | Vmax app (μM NADH min−1) | ||
|---|---|---|---|---|---|
| K0.5 (μM) | Hill | K0.5 (μM) | Hill | ||
| WT | 45.6 | 7.4 | 44.9 | 5.3 | 2.2 ± 0.1 |
| G113E | 17.6 | 2.3 | 44.9 | 2.8 | 2.4 ± 0.8 |
| G113R | 20.1 | 2.8 | 31.5 | 3.3 | 2.0 ± 0.5 |
| G207R | 35.5 | 2.8 | 37.1 | 5.8 | 2.1 ± 0.1 |
| S160del | 15.1 | 2.8 | 25.8 | 5.7 | 1.7 ± 0.2 |
| Q243H | 52.1 | 4.9 | 60.2 | 3.0 | 3.6 ± 0.5 |
| L245P | 16.9 | 1.7 | 24.6 | 3.5 | 2.8 ± 0.4 |
| K238R | 17.2 | 2.5 | 33.4 | 9.0 | 1.4 ± 0.1 |
