Table 1: Databases description.

This table provides the total number (n) of considered images (after quality control), the gender proportion, and the average ages and intervals in brackets.

	n	Sex	Age at first symptom Mean (years) [range]	Age at MRI Mean (years) [range]	EDSS Mean (years) [range]
HC subjects	38295	F = 19025; M = 19270	n.a	57.5 [0.7 – 100.2]	n.a
MS patients	2649	F = 1917; M = 732	32.1 [5 – 73]	42.1 [13 – 79]	2.6 [0 – 9]