Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2023 Mar 19:2023.03.16.532975. [Version 1] doi: 10.1101/2023.03.16.532975

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Extended Data Fig. 15: — Representative 3D images of A549 cells (top) and HeLa cells (bottom) in 3D matrices after 72-hr culture. Cells were transduced to express GFP-CaaX via lentiviral infection. In the x-y projections, cells are colour-coded according to their depth in the matrix. In the x-z projections, cells are coloured in green and merged with the ECM (magenta). Cells can infiltrate into 3D matrices of vitronectin fibres, but not into 3D matrices of pure collagen fibres. The shRNA knockdown of FCHo2, ITGβ5, or both significantly inhibit cell infiltrations into 3D ECMs. Scale bars: 100 μm.