Skip to main content
[Preprint]. 2023 Mar 21:2023.03.20.533396. [Version 1] doi: 10.1101/2023.03.20.533396

Fig 5. rTMS leads to duration and intensity dependant overstimulation for intermittent Theta Burst Stimulation (iTBS).

Fig 5.

(A) US FDA approved iTBS protocol consists of 600 pulses distributed across ON times of 2 s and OFF times of 8 s. The ON times consist of ten bursts of stimulus pulses at 5 Hz, where each burst consists of 3 pulses occurring at 50 Hz. (B) iTBS applied at peak amplitude (c, as defined in Fig 2C) resulted in the strongest firing rate response and the largest network connectivity upshoot. (C) iTBS at increasing stimulation duration (i.e., pulse numbers) was found to cause increasing values of post-stimulation connectivity upshoot among stimulated neurons. This trend was tested for iTBS, cTBS and 10 Hz and is summarised as log-log plots in (D).