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[Preprint]. 2023 Mar 24:2023.03.23.533923. [Version 1] doi: 10.1101/2023.03.23.533923

Figure 4. Crystal structures of (+)-BNM-III-170, TFH-070-A6, TFH-I-116-D-1,TFH-II-151, ZXC-I-090, ZXC-I-092, DL-I-101, and DL-I-102 derivatives in complex with a gp120CRF01_AE LMHS or LMHT coree.

Figure 4.

(A) and (B) (+)-BNM-III-170, (S)-MCG-IV-210, and piperidine analogs within the Phe43 cavity (A) gp120 is shown as a surface with the B20-21 loop region and D368 colored pale yellow and green, respectively. (B) gp120 is show as ribbon with the B21-21 loop region colored yellow, and D368 and Ser/Thr375 are shown as green sticks or as a blue sphere. (C) Superimposition of the piperidine derivatives onto (+)-BNM-III-170 and (S)-MCG-IV-210.