Figure 1: Models for the functions of actin assembly and myosin activity during membrane deformation for clathrin-mediated endocytosis.

Cartoon diagram illustrating the organization of actin filaments and Myo5 molecules at endocytic sites. Actin filaments are bound by coat proteins at the tip of the growing membrane invagination and oriented with their growing ends toward the plasma membrane, powering membrane invagination. The type I myosin Myo5 could either anchor the actin network in a favorable orientation (left) or provide an assisting force (right).