Table 1. ΔmptA is more sensitive to β-lactam antibiotics.

MIC, minimum inhibitory concentration. A non-growthinhibitory dose of 50 μg/mL sulbactam was added to inhibit β-lactamases. Known primary drug targets are: isoniazid, the outer membrane biosynthesis; vancomycin and moenomycin, cell wall transglycosylation; ampicillin, cell wall transpeptidation (primarily D-D crosslinks); meropenem, cell wall transpeptidation; (primarily L-D crosslinks); d-cycloserine, cytoplasmic cell wall precursor synthesis; and kanamycin, ribosome.

	MIC (μg/mL)
Antibiotic (+ 50 μg/mL sulbactam)	WT	ΔmptA	Fold change in sensitivity (ΔmptA/WT)
Isoniazid	25.0	20.8	1.2
Vancomycin	0.8	0.4	2.0
Moenomycin	0.8	0.2	4.0
Ampicillin	8.3	0.2	42.7
Meropenem	6.3	0.8	8.0
D-cycloserine	83.3	50.0	1.7
Kanamycin	2.1	0.8	2.7