Figure 5.

Clinical milestones of primary progressive aphasia evolution

The Figure summarises milestone symptoms and associated management implications over the clinical course of primary progressive aphasia syndromes, as identified from the caregiver survey. The left-hand panels show symptoms which (in that phase of the illness) are more prominent in some PPA syndromes than others; the middle panels show symptoms common to all syndromes. The right-hand panels represent key implications for management during each phase of the illness, as predicted from these milestone symptoms. Written symptom labels are colour-coded based on domains of verbal communication (black), nonverbal thinking (blue), nonverbal conduct and wellbeing (red) and physical symptoms (green) (see text for details).