Fig. 5. Prioritization of candidates associated with retina defects by in silico WB-subtraction.
(A) Comparison of top 30 retina expressed proteins with the top 30 retina “enriched-expression” proteins shows that 1/3rd of the candidates in the “enriched-expression” category are associated with the retinal defects (highlighted in grey) and are not amongst the top proteins expressed in the retina.
(B) Aldh1a1, Tyr, Pmel, Hmcn1, Rlbp1, Hras, Lama5, Egfr, Heph and Tenm3 associated with retinal defects that were not present in the top 30 “expressed” candidates show significant (p<0.001) enrichment in the retina compared to WB, demonstrating the effectiveness of the in silico WB-subtraction strategy in identifying these candidates from 2,675 expressed proteins. The average SpC of individual proteins are shown in y-axis.