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[Preprint]. 2023 Mar 15:rs.3.rs-2627723. [Version 1] doi: 10.21203/rs.3.rs-2627723/v1

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Figure 1. — (A) Co-crystal structures of SARS-CoV-2 M^pro in complex with nirmatrelvir (PDB:7SI9), ensitrelvir (PDB:7VU6), or FB2001 (PDB:6LZE). Labeled residues are interrogated in panel B.

(B) Fold-change in IC₅₀ relative to WT for the indicated mutants using the live cell gain-of-signal assay in 293T cells.