Table 1.
Hazard of AD with NRTI time-dependent exposure, Cox models in original and propensity score (PS)-matched populations.
| Original group HR (95% CI) |
PS matched HR (95% CI) |
|
|---|---|---|
| VA Time-dependent exposure: | ||
| NRTI use per year | 0.915 (0.89, 0.94) | 0.907 (0.862, 0.955) |
| Marketscan Time-dependent exposure: | ||
| NRTI use per year | 0.894 (0.845, 0.947) | 0.877 (0.821, 0.936) |
| VA Competing Risk of Mortality: | ||
| NRTI use per year | 0.456 (0.371, 0.56) | 0.514 (0.374, 0.706) |
| Model covariates | ||
| Age | Race | Sex |
| Charlson comorbidity index | Body mass index | Smoker |
| Pure hypercholesterolemia | Hypertriglyceridemia | Hyperlipidemia |
| Ischemic heart disease | Other heart disease | Hypertension |
| Type 2 diabetes mellitus | Cerebral infarction | Atrial fibrillation |
| Hypothyroidism | Hyperthyroidism | Depression |
| Traumatic Brain Injury | Alcohol dependence | Parkinson's disease |
| Generalized anxiety disorder | Chronic kidney disease | |
Hazard ratios based on a Cox proportional-hazards model for the original and propensity score (PS)-matched populations in the VA and Marketscan databases, adjusted for the confounding variables listed under Model covariates. Hazard ratios for covariates presented in Supplementary Tables 3 and 4.