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[Preprint]. 2023 Mar 20:2023.03.19.23287456. [Version 1] doi: 10.1101/2023.03.19.23287456

Figure 1 – SARS-CoV-2 viral RNA levels and antibody responses stratified by pregnancy and vaccination status.

Figure 1 –

Remnant clinical upper respiratory tract specimens were used determine rates of infectious virus recovery (A), viral RNA level (B), and anti-spike (ancestral spike) IgG titers (C) from mucosal swab samples. In (A), a positive cytopathic effect (CPE) in tissue culture was indicative of the presence of infectious virus. The dashed line in (B) represents the cutoff value (Ct ≤20) between high viral RNA and low viral levels, and the red text indicates the percentage of participants with Ct values > 20 (low viral RNA levels). The dashed line in (C) represents the limit of detection, and the red text indicates the percentage of non-responders (results below the limit of detection). Multivariate logistic regression was used to assess the correlation between anti-spike IgG titer and the probability of recovery of infectious virus (D). Analysis included Fisher’s exact test (A) and) and two-way ANOVAs with Tukey’s multiple comparisons test (B-C). *P < 0.05, *** P < 0.001, **** P < 0.0001. anti-S IgG, anti-ancestral strain spike immunoglobulin G; AUC, area under the curve; Ct, cycle threshold; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.