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[Preprint]. 2023 Mar 16:rs.3.rs-2675436. [Version 1] doi: 10.21203/rs.3.rs-2675436/v1

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Unsupervised hierarchical clustering of methylation M-values from the top 10,000 most variable probes in the 850K EPIC Methylation Beadchip array demonstrates distinct clustering of DNA samples derived from peripheral blood (cluster 1), adjacent non-diseased kidney (cluster 2), a cluster of predominantly BWT (cluster 3), and a cluster of predominantly unilateral WT (cluster 4). Within the BWT cluster (cluster 3), samples with 11p15.5 LOH, 11p15.5 LOI, and 11p15.5 ROI cluster together. Notably, the BWT cluster (cluster 3) joins with adjacent non-diseased kidney (cluster 2) more closely than the unilateral WT cluster. Germline type: G1 – blood, G2 – kidney. Histology – DA – diffuse anaplasia, FA – focal anaplasia, FH – favorable histology. Tumor type: G – germline sample, D – primary tumor sample, M – metastatic sample, X – patient-derived xenograft.