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. 2023 Mar 14;15(3):747. doi: 10.3390/v15030747

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PI attenuated the RV–A16-mediated regulation of genes involved in replication organelle (RO) formation and function. (A) Heat map of scaled average normalized expression for each condition: (1) uninfected (mock), (2) treated with PI alone (PI), (3) virus-infected (RV–A16), and (4) virus-infected and treated with PI (RV16 + PI) for RV–A16–regulated genes involved in RO formation and function. (B) Schematic of the RV-A16 replication cycle and the possible mechanisms of action of the PI liposome on RO formation and function.