Figure 1.

Placental pathology in Hb Bart’s disease. (a) The placenta belonging to Hb Bart’s disease shows enlarged, pale, and edematous cut surfaces in comparison to the placenta of non-Hb Bart’s disease (d). (b) Immature intermediate villi with a bulbous contour possessing conspicuous myofibroblasts at the periphery beneath the trophoblastic layer referred to as peripheral villous stromal hypercellularity in comparison to the control (e) (hematoxylin and eosin, original magnification ×400). (c) A branching vascular pattern with increased vessel number and endothelial thickness in comparison to the control (f) (CD34 immunostaining, original magnification ×600).